Intellectual Properties 

 

• 2024 | Mohamad Shazeli Che Zain, Faiqah Ramli, Leo Teik Kee, Ahmad Safiyyu'd-din Hisamuddin, Tham Chau Ling, Daud Ahmad Israf Ali, Khozirah Shaari, Chan Yee Han, Siti Munirah Mohd Faudzi and Sazlinda Kamaruzaman. A Melicope Ptelefolia Enriched Extract As Alternative for Eczema Treatment. Malaysia, PI2024006146, 24 October 2024 (Patent application)

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• 2021 | Mohamad Shazeli Che Zain, Sharida Fakurazi and Khozirah Shaari. A Green Process for Preparing A Flavonoid-Enriched Extract from Oil Palm (Elaeis guineensis Jacq.) Leaves. Malaysia, UI2021006246. 18 October 2021. (Utility Innovation application)

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• 2019 | Mohamad Shazeli Che Zain, Sharida Fakurazi and Khozirah Shaari. A Method of Extracting A Flavonoid Enriched Extract from A Plant and A Wound Healing Composition Comprising Thereof. Malaysia, PI2019004359, 29 July 2019 (Patent application)

 

 

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Journal Publications

 

• 2026 | Hisamuddin, A. S. D. D., Ramli, F., Leo, T. K., Zain, M. S. C., Wong, M. S., Suhaili, M. R., ... & Lee, T. Y. Adaptogenic Effects of Mushroom Blend Supplementation on Stress, Fatigue, and Sleep: A Randomised, Double‐Blind, and Placebo‐Controlled Trial. Brain and Behavior, 16(1), e71193. (Q2). (https://doi.org/10.1002/brb3.71193).​

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• 2026 | Aljawarneh, R. Y. A., Gan, C. Y., & Che Zain, M. S. Simultaneous optimization and adsorption/desorption characteristics of total flavonoid from kenaf (Hibiscus cannabinus L.) onto macroporous adsorption resins and evaluation on their flavonoid profiling and in vitro antioxidant properties. Journal of Food Measurement and Characterization, 1-19. (Q2). (https://doi.org/10.1007/s11694-026-04052-z).​

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• 2026 | Hadezir N.A., Che Zain, M. S., & Ismail, N.I. Valorization of Malaysian agro-industrial by-products: A comparative study of antioxidant properties in standardized NaDES-polyphenol enriched extracts. Contemporary Research in Natural Products, 1(1). (https://crnpmnps.com/index.php/CRNP/article/view/15).

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• 2025 | Ali, S.R., Che Zain, M.S. & Yahya, E.B. Biopolymers in sustainable agriculture: A review on their roles in precision farming and composite fertilizers. Polym. Bull. 83, 16 (Q2). (https://doi.org/10.1007/s00289-025-06069-8​).

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• 2025 | Joey, N.L., Ismail, N.A., Ahmad Mokhtar, A.M. & Che Zain, M.S. Integrated ultrasonic–natural deep eutectic solvent-assisted extraction for standardizing polyphenol-enriched extract from cocoa (Theobroma Cacao L.) rind with enhanced antioxidant properties. Food Measurement and Characterization (Q2). (https://doi.org/10.1007/s11694-025-03673-0).

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• 2025 | Aljawarneh, R. Y. A., Che Zain, M. S., & Zakaria, F. Standardized flavonoid-enriched extract from kenaf (Hibiscus cannabinus L.) promotes cutaneous wound healing in non-diabetic and diabetic model of adult zebrafish (Danio rerio) using non-invasive technique. Biocatalysis and Agricultural Biotechnology (69): 103772. (Q2) (https://doi.org/10.1016/j.bcab.2025.103772)

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• 2025 | Chandiran, C.V. and Che Zain, M.S. Transforming Commodity Crop Byproducts Into Carbon-Based Adsorbents for Flavonoid Recovery: A Review on Key Pyrolysis Parameters, Chemical Activation, and Adsorption Mechanisms. Journal of Separation Science 48(9), e70252. (Q2) (https://doi.org/10.1002/jssc.70252)

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• 2025 | David, P. A., Norazhar, A. I., & Che Zain, M. S. Integrating LC‐MS/MS and Molecular Networking for Advance Analysis and Comprehensive Flavonoids Annotation. Journal of Separation Science, 48(7), e70230. (Q2) (https://doi.org/10.1002/jssc.70230)

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• 2025 | Aljawarneh, R. Y. A., Che Zain, M. S., & Zakaria, F. Valorization of kenaf (Hibiscus cannabinus L.) into high‐value therapeutic agents: an updated review on extraction techniques, phytochemicals, pharmacological activities and encapsulation technologies. Journal of the Science of Food and Agriculture. (Q1) (https://doi.org/10.1002/jsfa.70033)

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• 2025 | Ahmad, A., Abdul Khalil, H. P. S., Bairwan, R. D., Ahmad, M. I., Abdullah, A. A. A., Abdullah, C. K., ... & Hamid, S. A. (2025). Sustainable cellulose extraction: unlocking the potential of tropical fruit peels for advanced materials. Clean Technologies and Environmental Policy, 27(2), 919-951. (Q2) (https://doi.org/10.1007/s10098-024-03110-8)

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• 2025 | Azfaralariff, A., Razali, N., Abdul Khalil, H. P. S., Ahmad, M. I., Abdullah, C. K., Yahya, E. B., ... & Zain, M. S. C. (2025). Transforming agricultural waste into sustainable bioadsorbents and advanced bioaerogels from durian (Durio zibethinus) peel. Biofuels, Bioproducts and Biorefining. (Q2) (https://doi.org/10.1002/bbb.2771)

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• 2025 | Yahya, E. B., Ali, S. R., Lalung, J., Zain, M. S. C., Danish, M., & John, A. (2025). Exploring the potential of biopolymers in cosmetic applications: Sustainable, biocompatible, and high‐performance materials for future innovations. Polymer Engineering & Science, 65(6), 2789-2802. (Q2) (https://doi.org/10.1002/pen.27186)

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• 2024 | Chan, W. S., Teoh, K. X., Leong Joey, N., & Che Zain, M. S. Spray Drying Microencapsulation of Antioxidant Bioflavonoids: A Bibliometric Analysis and Review on Recent Research Landscape (2013–2023) and Process Optimization. Journal of Food Process Engineering, 47(11), e14766. (Q2) (https://doi.org/10.1111/jfpe.14766)

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• 2024 | Chan, W. S., Che Zain, M. S., & Ahmad Mokhtar, A. M. Microencapsulation of Elaeis guineensis leaf extract powder enriched with bioflavonoid preserves its antioxidant and anti-inflammatory properties: spray drying optimization and powder characterization. Journal of Food Measurement and Characterization, 18(12), 10182-10201. (Q2) (https://doi.org/10.1007/s11694-024-02960-6)

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• 2024 | Che Zain, M. S., Danish, M., Shaari, K., & Fakurazi, S. One-pot synthesis of polysaccharide / gelatin amorphous hydrogels impregnated with a bioflavonoid derived from Elaeis guineensis leaf: wound healing and drug release properties. DARU Journal of Pharmaceutical Sciences, 32 (2), 689 - 703. (Q3)  (https://doi.org/10.1007/s40199-024-00540-z)

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• 2024 | Aljawarneh, R. Y. A., Che Zain, M. S., & Zakaria, F. Macroporous polymeric resin for the purification of flavonoids from medicinal plants: A review. Journal of Separation Science, 47(15), 2400372. (Q2) (https://doi.org/10.1002/jssc.202400372) 

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• 2024 | Che Zain, M. S. Emerging botanical processing technology of bioflavonoid for sustainable production of high value standardized nutraceutical ingredients: a review. Journal of Food Measurement and Characterization, 18(7), 5602-5621. (Q2) (https://doi.org/10.1007/s11694-024-02591-x) 

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• 2024 | Che Zain, M. S., Shaari, K., Lee, S. Y., & Fakurazi, S. Development and Evaluation of Hydrogel-Thickened Nanoemulsion Containing Orientin, Isoorientin, Vitexin and Isovitexin as an Antioxidant Wound Dressing. Journal of Cluster Science, 35(2), 635-656. (Q2) (https://doi.org/10.1007/s10876-023-02504-w) 

 

• 2023 | Sarian, M. N., Zulkefli, N., ZAIN, S., Maniam, S., & Fakurazi, S. A review with updated perspectives on in vitro and in vivo wound healing models. Turkish journal of biology, 47(4), 236-246. (Q3) (https://doi.org/10.55730/1300-0152.2659) 

 

• 2023 | Aldurrah, Z., Kauli, F. S. M., Rahim, N. A., Zainal, Z., Afzan, A., Al Zarzour, R. H., ... & Zakaria, F. Antidepressant evaluation of Andrographis paniculata Nees extract and andrographolide in chronic unpredictable stress zebrafish model. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 271, 109678. (Q2) (https://doi.org/10.1016/j.cbpc.2023.109678) 

 

• 2021 | Che Zain, M. S., Yeoh, J. X., Lee, S. Y., Afzan, A., & Shaari, K. Integration of choline chloride-based natural deep eutectic solvents and macroporous resin for green production of enriched oil palm flavonoids as natural wound healing agents. Antioxidants, 10(11), 1802. (Top 10%) (https://doi.org/10.3390/antiox10111802) 

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• 2021 | Che Zain, M. S., Lee, S. Y., Teo, C. Y., & Shaari, K. Adsorption/desorption characteristics and simultaneous enrichment of orientin, isoorientin, vitexin and isovitexin from hydrolyzed oil palm leaf extract using macroporous resins. Processes, 9(4), 659. (Q2) (https://doi.org/10.3390/pr9040659) 

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• 2021 | Che Zain, M. S., Osman, M. F., Lee, S. Y., & Shaari, K. UHPLC-UV/PDA method validation for simultaneous quantification of luteolin and apigenin derivatives from Elaeis guineensis leaf extracts: An application for antioxidant herbal preparation. Molecules, 26(4), 1084. (Q2) (https://doi.org/10.3390/molecules26041084) 

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• 2021 | Che Zain, M. S., Edirisinghe, S. L., Kim, C. H., De Zoysa, M., & Shaari, K. Nanoemulsion of flavonoid-enriched oil palm (Elaeis guineensis Jacq.) leaf extract enhances wound healing in zebrafish. Phytomedicine Plus, 1(4), 100124. (https://doi.org/10.1016/j.phyplu.2021.100124) 

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• 2021 | Che Zain, M. S., Yeoh, J. X., Lee, S. Y., & Shaari, K. (2021). Physicochemical properties of choline chloride-based natural deep eutectic solvents (NaDES) and their applicability for extracting oil palm flavonoids. Sustainability, 13(23), 12981. (Q2) (https://doi.org/10.3390/su132312981) 

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• 2020 | Che Zain, M. S., Lee, S. Y., Sarian, M. N., Fakurazi, S., & Shaari, K. (2020). In vitro wound healing potential of flavonoid c-glycosides from oil palm (Elaeis guineensis Jacq.) leaves on 3t3 fibroblast cells. Antioxidants, 9(4), 326. (Top 10%) (https://doi.org/10.3390/antiox9040326)

 

• 2020 | Che Zain, M. S., Lee, S. Y., Teo, C. Y., & Shaari, K. (2020). Adsorption and desorption properties of total flavonoids from oil palm (Elaeis guineensis Jacq.) mature leaf on macroporous adsorption resins. Molecules, 25(4), 778. (Q2) (https://doi.org/10.3390/molecules25040778)

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• 2020 | Che Zain, M. S., Jakariah, N. A., Yeoh, J. X., Lee, S. Y., & Shaari, K. Ultrasound-assisted extraction of polyphenolic contents and acid hydrolysis of flavonoid glycosides from oil palm (Elaeis guineensis Jacq.) leaf: Optimization and correlation with free radical scavenging activity. Processes, 8 (12), 1540. (Q2) (https://doi.org/10.3390/pr8121540) 

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• 2020 | Che Zain, M. S., Lee, S. Y., Nasir, N. M., Fakurazi, S., & Shaari, K. Metabolite characterization and correlations with antioxidant and wound healing properties of oil palm (Elaeis guineensis Jacq.) leaflets via 1H-NMR-based metabolomics approach. Molecules, 25(23), 5636. (Q2) (https://doi.org/10.3390/molecules25235636)

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Chapter in Books

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• 2021 | Mohamad Shazeli Che Zain and Khozirah Shaari. (2021). Antioxidant, Bioflavonoid-Enriched Extract from Oil Palm Leaves (Elaeis guineensis) for Wound Care. Wonders of Natural Products in Malaysia, UNIMAS, 9 Dec 2021.

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Proceedings

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• 2021 | Mohamad Shazeli Che Zain, Soo Yee Lee, Nadiah Mad Nasir, Sharida Fakurazi and Khozirah Shaari. Waste to Wealth: Transforming Low-Value Oil Palm Leaf Biomass into A Potent Wound Healing Agent. Proceeding in Penang International Invention, Innovation and Design Competition 2021, Universiti Teknologi Mara, Penang, Malaysia. e-ISBN: 978-967-0841-95-3.

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• 2021 | Mohamad Shazeli Che Zain, Soo Yee Lee, Nadiah Mad Nasir, Sharida Fakurazi and Khozirah Shaari. Waste to Health: An Integrated Sustainable Process for Extraction and Enrichment of Flavonoids as High-Value Chemicals from Oil Palm Leaves. Proceeding in E-Symposium on Green Transformation of Agro Wastes 2021. Monash University, Selangor, Malaysia