Intellectual Properties 

 

• 2024 | Mohamad Shazeli Che Zain, Faiqah Ramli, Leo Teik Kee, Ahmad Safiyyu'd-din Hisamuddin, Tham Chau Ling, Daud Ahmad Israf Ali, Khozirah Shaari, Chan Yee Han, Siti Munirah Mohd Faudzi and Sazlinda Kamaruzaman. A Melicope Ptelefolia Enriched Extract As Alternative for Eczema Treatment. Malaysia, PI2024006146, 24 October 2024 (Patent application)

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• 2021 | Mohamad Shazeli Che Zain, Sharida Fakurazi and Khozirah Shaari. A Green Process for Preparing A Flavonoid-Enriched Extract from Oil Palm (Elaeis guineensis Jacq.) Leaves. Malaysia, UI2021006246. 18 October 2021. (Utility Innovation application)

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• 2019 | Mohamad Shazeli Che Zain, Sharida Fakurazi and Khozirah Shaari. A Method of Extracting A Flavonoid Enriched Extract from A Plant and A Wound Healing Composition Comprising Thereof. Malaysia, PI2019004359, 29 July 2019 (Patent application)

 

 

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Journal Publications

 

• 2025 | Joey, N.L., Ismail, N.A., Ahmad Mokhtar, A.M. & Che Zain, M.S. Integrated ultrasonic–natural deep eutectic solvent-assisted extraction for standardizing polyphenol-enriched extract from cocoa (Theobroma Cacao L.) rind with enhanced antioxidant properties. Food Measurement and Characterization (Q2). (https://doi.org/10.1007/s11694-025-03673-0).

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• 2025 | Aljawarneh, R. Y. A., Che Zain, M. S., & Zakaria, F. Standardized flavonoid-enriched extract from kenaf (Hibiscus cannabinus L.) promotes cutaneous wound healing in non-diabetic and diabetic model of adult zebrafish (Danio rerio) using non-invasive technique. Biocatalysis and Agricultural Biotechnology (69): 103772. (Q2) (https://doi.org/10.1016/j.bcab.2025.103772)

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• 2025 | Chandiran, C.V. and Che Zain, M.S. Transforming Commodity Crop Byproducts Into Carbon-Based Adsorbents for Flavonoid Recovery: A Review on Key Pyrolysis Parameters, Chemical Activation, and Adsorption Mechanisms. Journal of Separation Science 48(9), e70252. (Q2) (https://doi.org/10.1002/jssc.70252)

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• 2025 | David, P. A., Norazhar, A. I., & Che Zain, M. S. Integrating LC‐MS/MS and Molecular Networking for Advance Analysis and Comprehensive Flavonoids Annotation. Journal of Separation Science, 48(7), e70230. (Q2) (https://doi.org/10.1002/jssc.70230)

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• 2025 | Aljawarneh, R. Y. A., Che Zain, M. S., & Zakaria, F. Valorization of kenaf (Hibiscus cannabinus L.) into high‐value therapeutic agents: an updated review on extraction techniques, phytochemicals, pharmacological activities and encapsulation technologies. Journal of the Science of Food and Agriculture. (Q1) (https://doi.org/10.1002/jsfa.70033)

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• 2025 | Ahmad, A., Abdul Khalil, H. P. S., Bairwan, R. D., Ahmad, M. I., Abdullah, A. A. A., Abdullah, C. K., ... & Hamid, S. A. (2025). Sustainable cellulose extraction: unlocking the potential of tropical fruit peels for advanced materials. Clean Technologies and Environmental Policy, 27(2), 919-951. (Q2) (https://doi.org/10.1007/s10098-024-03110-8)

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• 2025 | Azfaralariff, A., Razali, N., Abdul Khalil, H. P. S., Ahmad, M. I., Abdullah, C. K., Yahya, E. B., ... & Zain, M. S. C. (2025). Transforming agricultural waste into sustainable bioadsorbents and advanced bioaerogels from durian (Durio zibethinus) peel. Biofuels, Bioproducts and Biorefining. (Q2) (https://doi.org/10.1002/bbb.2771)

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• 2025 | Yahya, E. B., Ali, S. R., Lalung, J., Zain, M. S. C., Danish, M., & John, A. (2025). Exploring the potential of biopolymers in cosmetic applications: Sustainable, biocompatible, and high‐performance materials for future innovations. Polymer Engineering & Science, 65(6), 2789-2802. (Q2) (https://doi.org/10.1002/pen.27186)

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• 2024 | Chan, W. S., Teoh, K. X., Leong Joey, N., & Che Zain, M. S. Spray Drying Microencapsulation of Antioxidant Bioflavonoids: A Bibliometric Analysis and Review on Recent Research Landscape (2013–2023) and Process Optimization. Journal of Food Process Engineering, 47(11), e14766. (Q2) (https://doi.org/10.1111/jfpe.14766)

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• 2024 | Chan, W. S., Che Zain, M. S., & Ahmad Mokhtar, A. M. Microencapsulation of Elaeis guineensis leaf extract powder enriched with bioflavonoid preserves its antioxidant and anti-inflammatory properties: spray drying optimization and powder characterization. Journal of Food Measurement and Characterization, 18(12), 10182-10201. (Q2) (https://doi.org/10.1007/s11694-024-02960-6)

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• 2024 | Che Zain, M. S., Danish, M., Shaari, K., & Fakurazi, S. One-pot synthesis of polysaccharide / gelatin amorphous hydrogels impregnated with a bioflavonoid derived from Elaeis guineensis leaf: wound healing and drug release properties. DARU Journal of Pharmaceutical Sciences, 32 (2), 689 - 703. (Q3)  (https://doi.org/10.1007/s40199-024-00540-z)

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• 2024 | Aljawarneh, R. Y. A., Che Zain, M. S., & Zakaria, F. Macroporous polymeric resin for the purification of flavonoids from medicinal plants: A review. Journal of Separation Science, 47(15), 2400372. (Q2) (https://doi.org/10.1002/jssc.202400372) 

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• 2024 | Che Zain, M. S. Emerging botanical processing technology of bioflavonoid for sustainable production of high value standardized nutraceutical ingredients: a review. Journal of Food Measurement and Characterization, 18(7), 5602-5621. (Q2) (https://doi.org/10.1007/s11694-024-02591-x) 

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• 2024 | Che Zain, M. S., Shaari, K., Lee, S. Y., & Fakurazi, S. Development and Evaluation of Hydrogel-Thickened Nanoemulsion Containing Orientin, Isoorientin, Vitexin and Isovitexin as an Antioxidant Wound Dressing. Journal of Cluster Science, 35(2), 635-656. (Q2) (https://doi.org/10.1007/s10876-023-02504-w) 

 

• 2023 | Sarian, M. N., Zulkefli, N., ZAIN, S., Maniam, S., & Fakurazi, S. A review with updated perspectives on in vitro and in vivo wound healing models. Turkish journal of biology, 47(4), 236-246. (Q3) (https://doi.org/10.55730/1300-0152.2659) 

 

• 2023 | Aldurrah, Z., Kauli, F. S. M., Rahim, N. A., Zainal, Z., Afzan, A., Al Zarzour, R. H., ... & Zakaria, F. Antidepressant evaluation of Andrographis paniculata Nees extract and andrographolide in chronic unpredictable stress zebrafish model. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 271, 109678. (Q2) (https://doi.org/10.1016/j.cbpc.2023.109678) 

 

• 2021 | Che Zain, M. S., Yeoh, J. X., Lee, S. Y., Afzan, A., & Shaari, K. Integration of choline chloride-based natural deep eutectic solvents and macroporous resin for green production of enriched oil palm flavonoids as natural wound healing agents. Antioxidants, 10(11), 1802. (Top 10%) (https://doi.org/10.3390/antiox10111802) 

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• 2021 | Che Zain, M. S., Lee, S. Y., Teo, C. Y., & Shaari, K. Adsorption/desorption characteristics and simultaneous enrichment of orientin, isoorientin, vitexin and isovitexin from hydrolyzed oil palm leaf extract using macroporous resins. Processes, 9(4), 659. (Q2) (https://doi.org/10.3390/pr9040659) 

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• 2021 | Che Zain, M. S., Osman, M. F., Lee, S. Y., & Shaari, K. UHPLC-UV/PDA method validation for simultaneous quantification of luteolin and apigenin derivatives from Elaeis guineensis leaf extracts: An application for antioxidant herbal preparation. Molecules, 26(4), 1084. (Q2) (https://doi.org/10.3390/molecules26041084) 

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• 2021 | Che Zain, M. S., Edirisinghe, S. L., Kim, C. H., De Zoysa, M., & Shaari, K. Nanoemulsion of flavonoid-enriched oil palm (Elaeis guineensis Jacq.) leaf extract enhances wound healing in zebrafish. Phytomedicine Plus, 1(4), 100124. (https://doi.org/10.1016/j.phyplu.2021.100124) 

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• 2021 | Che Zain, M. S., Yeoh, J. X., Lee, S. Y., & Shaari, K. (2021). Physicochemical properties of choline chloride-based natural deep eutectic solvents (NaDES) and their applicability for extracting oil palm flavonoids. Sustainability, 13(23), 12981. (Q2) (https://doi.org/10.3390/su132312981) 

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• 2020 | Che Zain, M. S., Lee, S. Y., Sarian, M. N., Fakurazi, S., & Shaari, K. (2020). In vitro wound healing potential of flavonoid c-glycosides from oil palm (Elaeis guineensis Jacq.) leaves on 3t3 fibroblast cells. Antioxidants, 9(4), 326. (Top 10%) (https://doi.org/10.3390/antiox9040326)

 

• 2020 | Che Zain, M. S., Lee, S. Y., Teo, C. Y., & Shaari, K. (2020). Adsorption and desorption properties of total flavonoids from oil palm (Elaeis guineensis Jacq.) mature leaf on macroporous adsorption resins. Molecules, 25(4), 778. (Q2) (https://doi.org/10.3390/molecules25040778)

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• 2020 | Che Zain, M. S., Jakariah, N. A., Yeoh, J. X., Lee, S. Y., & Shaari, K. Ultrasound-assisted extraction of polyphenolic contents and acid hydrolysis of flavonoid glycosides from oil palm (Elaeis guineensis Jacq.) leaf: Optimization and correlation with free radical scavenging activity. Processes, 8 (12), 1540. (Q2) (https://doi.org/10.3390/pr8121540) 

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• 2020 | Che Zain, M. S., Lee, S. Y., Nasir, N. M., Fakurazi, S., & Shaari, K. Metabolite characterization and correlations with antioxidant and wound healing properties of oil palm (Elaeis guineensis Jacq.) leaflets via 1H-NMR-based metabolomics approach. Molecules, 25(23), 5636. (Q2) (https://doi.org/10.3390/molecules25235636)

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Chapter in Books

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• 2021 | Mohamad Shazeli Che Zain and Khozirah Shaari. (2021). Antioxidant, Bioflavonoid-Enriched Extract from Oil Palm Leaves (Elaeis guineensis) for Wound Care. Wonders of Natural Products in Malaysia, UNIMAS, 9 Dec 2021.

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Proceedings

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• 2021 | Mohamad Shazeli Che Zain, Soo Yee Lee, Nadiah Mad Nasir, Sharida Fakurazi and Khozirah Shaari. Waste to Wealth: Transforming Low-Value Oil Palm Leaf Biomass into A Potent Wound Healing Agent. Proceeding in Penang International Invention, Innovation and Design Competition 2021, Universiti Teknologi Mara, Penang, Malaysia. e-ISBN: 978-967-0841-95-3.

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• 2021 | Mohamad Shazeli Che Zain, Soo Yee Lee, Nadiah Mad Nasir, Sharida Fakurazi and Khozirah Shaari. Waste to Health: An Integrated Sustainable Process for Extraction and Enrichment of Flavonoids as High-Value Chemicals from Oil Palm Leaves. Proceeding in E-Symposium on Green Transformation of Agro Wastes 2021. Monash University, Selangor, Malaysia